There are a number of conditions in which hypersegmented neutrophils may be seen, such as megaloblastic anemias (including folic acid deficiency and. BMJ Case Rep. Aug 17; pii: bcr doi: /bcr Hypersegmented neutrophils and oval macrocytes in the setting of. Hypersegmented neutrophils and reversible hyperpigmentation in vitamin B12 deficiency in Ghana. Ivy Adwowa Efiefi Ekem.

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Her symptoms cleared with vitamin B 12 treatment. Treatment is readily available for vitamin B 12 deficiency, so early recognition is important to ensure nsutrophils replacement therapy.

Anderson’s Atlas of Hypersegmsnted. Although several tests are available, investigating these patients is not simple. Views Read Edit View history. Br J Haematol ; She had no medical history of note.

Hypersegmented neutrophil – Wikipedia

Hypersegmentation can sometimes be difficult to assert since interobserver variation is high, and important to note is that blacks have a greater neutrophil segmentation than whites [3] [4]. Clinical chemistry Hematopathology Transfusion medicine Medical microbiology Diagnostic immunology Immunopathology Enzyme assay Mass spectrometry Chromatography Flow cytometry Blood bank Microbiological culture Serology.

Wintrobe’s Atlas of Clinical Hematology. In other projects Wikimedia Commons. The present report concerns three cases of vitamin B 12 deficiency in Ghana.

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Case 3 was a year-old Ghanaian woman. Blood Rev ; In this report, three cases of vitamin B 12 deficiency in Ghana are presented that hupersegmented some important laboratory and clinical observations that may be helpful for diagnosis in West Africa.

She was pale, had hyperpigmented soles and palms as hypersegmentd as abdominal neutgophils. The need for a pragmatic approach in diagnosing vitamin B 12 deficiency is stressed. From Wikipedia, the free encyclopedia. Galloway M, Macrocytosis Hamilton M: It is not clear to us what might have accounted for the high serum vitamin B 12 value, but high intrinsic factor antibodies have been reported to be a cause of such a finding.

She was continued on folic acid and steroids were added. Bacteremia Viremia Fungemia Parasitemia Algaemia. Ivy Adwowa Efiefi Ekem, moc. Vitamin B 12 deficiency.

The third patient presented with haemolytic anaemia with depression, and was managed as such initially. Normal concentrations of vitamin B 12 have been seen in patients with overt deficiency, while high levels neutrophios been seen in functional deficiencies, implying that careful examination to identify other signs of the vitamin deficiency is important.

Hypersegmentation can also be seen in many other condition but with relatively less neuutrophils significance. Please review our privacy policy. She was a retired educationist with adult children.

Blood sugar Hypoglycemia Hyperglycemia Prediabetes Impaired fasting glucose Impaired glucose tolerance Oxyhyperglycemia. The patient in case 2, had hyperpigmentation, numbness and loss of reflexes, anaemia, macrocytosis and hypersegmented neutrophils: She was a nurse with children and had undergone a hysterectomy 14 years previously for unclear reasons. Retrieved from ” https: Published online Sep The serum vitamin B 12 estimation had been performed by the same laboratory using the same method of chemiluminescence assay, an automated non-isotopic no-boil assay.

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Ivy Adwowa Efiefi Ekem. Support Center Support Center. In all three cases, no family member had had such an ailment. Desk Reference for Hematology, Second Edition. Recent reports show that serum vitamin B 12 value alone is insufficient for the diagnosis of vitamin B hypersegmenfed deficiency.

She presented with weakness, excessive salivation and anorexia for 24 weeks.

Hypersegmented neutrophils and oval macrocytes in the setting of B12 deficiency and pancytopaenia.

She was unemployed, lived with her father and had two children. She presented with neutophils jaundice, malaise, insomnia, joint pain, numbness and dark urine for more than 84 weeks.

Persisting vague neurological symptoms lead to a check of serum vitamin B 12which was found to be low.

Case 3 had anorexia, hyperpigmentation, neurological defects and anaemia with hypersegmented neutrophils on the blood film.