Chlorothiazide should be used cautiously in patients with renal disease resulting in severe renal impairment because the drug decreases the glomerular. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Diuril (Chlorothiazide). Chlorothiazide sodium for injection, USP is a diuretic and a vial containing: Chlorothiazide sodium equiva- . toxicity. Refer to the package insert for lithium.

Author: Kazrazil Nigis
Country: Bahamas
Language: English (Spanish)
Genre: Music
Published (Last): 18 December 2016
Pages: 385
PDF File Size: 2.84 Mb
ePub File Size: 15.50 Mb
ISBN: 580-6-31575-860-1
Downloads: 78292
Price: Free* [*Free Regsitration Required]
Uploader: Taushura

Drugs that are associated with depletion of electrolytes may cause cisapride-induced cardiac arrhythmias. In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. Concurrent use of topiramate with non-potassium sparing diuretics e.

At maximal therapeutic dosage all thiazides are approximately equal in their diuretic efficacy. Alcohol, barbiturates, or narcotics — potentiation of orthostatic hypotension may occur. Serotonin norepinephrine reuptake inhibitors: Relatively high doses of fish oil are required to produce any blood pressure lowering effect. In addition, use caution in patients receiving drugs where hypokalemia is a particular risk. As methadone may also prolong the QT interval, cautious coadministration with diuretics is needed.

Moderate During clinical trials with silodosin, the incidence of dizziness and orthostatic hypotension was higher in patients receiving concomitant antihypertensive treatment.

PDR Search

Moderate Thiazide diuretics can enhance the hypotensive effects of antihypertensive agents or diuretics if given concomitantly. Caution is advised when tizanidine is to be used in patients receiving concurrent antihypertensive therapy. When concurrent therapy with a thiazide diuretic and carbamazepine is necessary, monitor patients for hyponatremia. Moderate Concomitant administration of methoxsalen and other photosensitizing agents, such as thiazide diuretics, can increase the incidence or severity of photsensitization from either compound.


Diuril Oral Suspension mg/5mL, 8 oz. Bottle

During coadministration of NSAIDs and diuretic therapy, patients should be monitored for changes in the effectiveness of their diuretic therapy and for signs and symptoms of renal impairment. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts.

Directions for Reconstitution Use aseptic technique. There may also be an additive diuretic or hyperuricemic effect. Discontinuation of vortioxetine should be considered in patients who develop symptomatic hyponatremia. In those men with significant corpora cavernosa venous leakage, hypotension might be more likely.

Major Thiazide diuretics may cause the urine to become alkaline. Atypical antipsychotics may cause orthostatic hypotension and syncope, most commonly during treatment initiation and dosage increases. It is not known whether chlorothiazide can cause fetal harm; however, thiazides cross the placental barrier and appear in cord blood. Moderate Co-enzyme Q10, ubiquinone CoQ10 may lower blood pressure.

Chlorothiazide absorption from the GI tract is saturable. Moderate Thiazide diuretics can cause hypokalemia, hypomagnesemia, or hypercalcemia which may increase digoxin’s pharmacologic effect. Frequently monitor serum electrolytes if concomitant use of these drugs is necessary. Close monitoring of serum digoxin concentrations is essential to avoid enhanced toxicity.


Compatible with dextrose or sodium chloride IV solutions. Major Concurrent use of lithium and thiazide diuretics may result in lithium toxicity. If these drugs are used together, closely dluril for changes in blood pressure. Thiazides may decrease urinary calcium excretion. In addition, diuretics reduce the risk of stroke and cardiovascular disease in patients with diabetes.

Moderate The pharmacologic effects of isoproterenol may cause an increase in blood pressure. Patients should be informed about measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning, or rising slowly from a seated position.

Moderate Monitor serum sodium closely if tolvaptan and thiazide diuretics are used together. Moderate Patients receiving vilazodone with medications known to cause hyponatremia, such as diuretics, may be at increased risk of developing hyponatremia. Some patients develop significant hypotension shortly after administration of the first dose. Hyponatremia may be potentiated by agents which can cause sodium depletion such as diuretics.