Co-processed excipients have been developed to handle changes in the physical properties of particles at sub-particle levels. By co-processing two excipients. A co-processed excipient is any combination of 2 or more excipients obtained by physical co-processing that does not lead to the formation of. co-processed excipients ppt. 1. 1; 2. CO-PROCESSED Presented by- Under the guidance ofMr. Bhaskar N. Bangar Dr. N. H. Aloorkar.
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The friability of the granules was found out using Roche friabilator. Acacia was used in the form of mucilage.
Evaluations The different evaluation parameters of tablet like weight variation, hardness, friability, disintegration time, drug content, drug release etc. The drug-excipients interaction study was carried out using method descried in Cartensen and analysis done using FTIR spectrophotometer [ 13 ].
To determine dissolution profile, same principle was used as in disintegration test that small exci;ients of saliva. Due to its high swelling index the coprocessed mucilage shows faster disintegration than the coprocessed SSG.
The percentage friability was calculated with the following formula:. However, the numbers of excipients that can actually fulfill such performance requirements are limited. The property of mucilage like high swelling index prompted to explore its applications as disintegrating agent in tablet manufacturing [ 8 ]. The Kawakita plots were found out for the co-processed coprocesssd granules from the data obtained from the tapings. The comparative study between coprocessed SSG and coprocessed mucilage was done Figure 2.
Now the volume is noted as v o.
So, these were eliminated from the study. Saha S, Shahiwala AF Multifunctional coprocessed excipients for improved tabletting performance. Open in a separate window. Suitable dilutions were made and analyzed spectrophotometrically by measuring the absorbance at nm. Then small fraction of mixture was compressed on Automatic IR Press at pressure 10 tones to form transparent pellet. Indian Journal of Pharmaceutical Sciences All these parameters were also calculated for the co-processed excipient granules, granules of pure acacia and CaCO 3 in addition to the friability of granules.
The direct compression method is most widely accepted process for hydrophobic drugs to be formulated into tablet dosage forms. Results and Discussion Terbutaline sulphate is most commonly used drug in the treatment of asthma. Drug excipients compatibility study The drug-excipients interaction study was carried out using method descried in Cartensen and analysis done using FTIR spectrophotometer [ 13 ]. Expert Opin Drug Deliv 6: The more is the binder used, the more is the disintegration time for the tablets.
Despite their popularity, an obvious limitation of oral solid dosage form is difficulty of swallowing.
These damp mass were passed through 12 and the obtained granules were dried. Micromeritic properties of co-processing excipients formulated with different ratios of acacia mucilage and calcium carbonate. It was evaluated for different flow properties and disintegration time.
For this purpose, a beaker was filled with 10 ml of water. Evaluation of pre-compression parameters The following micromeritic properties were evaluated: The tapped coprcoessed was calculated by the formula: All the pre-compression parameters were calculated for the co-processed excipient granules, granules of pure acacia and CaCO 3 in addition to the friability of granules.
Developed tablets were evaluated for usual tablet tests such as weight variation, hardness, friability, drug content. The present study has been carried out to develop the co-processed excipients in the exciipents and development of atorvastatin calcium tablets using direct compression method. Acacia, alkalizer, calcium carbonate, granulation technique. It is for this reason that most drug delivery systems are currently administered in the form of tablets, capsules, powders, granules.
Preparation of mouth dissolving tablet The selected concentration of coprocessed mucilage was used in the preparation of mouth dissolving tablet.
Encyclopedia of Pharmaceutical Technology. To simulate the mechanical excipientts applied to mouth dissolving tablet in multi-dose containers, the friability method was used. Developing new grades of existing excipients or combination of existing excipients is successful alternative and that can be achieved by means of coprocessing [ 5 ].
The coprocessed mucilage shows the appropriate disintegration time.
After 30 days coprocsssed samples were withdrawn and characterized for weight variation, hardness, disintegration time, drug content and in vitro drug release study. CaCO 3 also acts as alkalizer and thus suitable to improve the dissolution rate of pH dependent soluble drugs like atorvastatin. Drug Stability Principles and Practices. Can’t read the image? The bulk density was calculated by the formula: The difficulty in swallowing is called as dysphagia.
Co-processed excipients were prepared to improve the process ability and efficacy of commonly used excipients and cooprocessed impart multi-functional qualities to the excipients and hence that the tablets with the desired attributes can be produced. A review of co-processed directly compressible excipients.
Drug Dev Ind Pharm.
Isolation of mucilage from Ocimum bascilium: Construction of Kawakita plots Estimation of degree of volume reduction A total of 3 g of granules were weighed and transferred to a measuring cylinder.
The fundamental powder properties such as morphology, particle size, shape, surface area, porosity and density influences excipient functionalities such as flow ability, compactability, dilution potential, disintegration potential and lubricant potential.