[ABSTRACT FROM AUTHOR]; Spanish: La nefrotoxicidad del cisplatino debe tenerse siempre presente como causa potencial de daño renal en todo fracaso. OBJECTIVE: To review recent advances in the understanding of the mechanisms of cisplatin nephrotoxicity. Factors affecting this toxicity and agents that may. Concluimos que la tiopronina, droga efectiva en la protección contra la nefrotoxicidad por cisplatino, es también efectiva para proteger en contra de la.

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Differential roles of hydrogen peroxide and hydroxyl radical in cisplatin-induced cell death in renal proximal tubular epithelial cells. These data supported other studies that indicated reductions in body weight could be attributable to toxic side effect of chemotherapeutic drugs and it suggests that T.

Studies on the protective effect of dietary fish oil on cisplatin induced nephrotoxicity in rats.

A combination of vitamin C and losartan for cisplatin-induced nephrotoxicity in rats. Protective effect of an aphrodisiac herb Tribulus terrestris Linn on cadmium-induced testicular damage.

Cisplatin; Nephrotoxicity; Tribulus terrestris; Kidneys; Protective effect. Accordingly, it is of particular interest to discover the effects of Tribulus terrestris L on cisplatin-induced apoptosis in mice kidney. Treatment of mice with CP resulted in renal damage, showing a significant decline in the weight of animals treated with CP.

Preventive effect of tert-butylhydroquinone on cisplatin-induced nephrotoxicity in rats. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. Hoboken7: Research protocols were approved by the local ethics committee. After 4 days of injections CIS in a dose of 5. Then, fresh fruits of T.


Nefrotoxicidad del cisplatino

Renal tubular apoptosis has been suggested as a mechanism of cisplatin-induced acute kidney injury. Zygophyllacea against mercuric chloride induced nephrotoxicity in mice, Mus musculus Linn. Zhong Yao Cai, 26 5: The kidneys were removed after 4 days of injections, and TUNEL assay on mice’s kidneys were performed.

Advances in flavonoid research since It is an efficient platinum-derived alkylating agent that acts in unspecific phases of the cellular cycle against proliferating and resting cells Lirdi et al. Tribulus terrestris L is also reported to have cooling, diuretic, tonic and aphrodisiac effects Sugunavarman et al. Treatment of cisplatin-treated mice with Ciwplatino.

Treatment of male mice with extract of T. Protective effects of the angiotensin II receptor blocker losartan on cisplatin-induced kidney injury. Cisplatin cis-diamminedichloroplatinum II CPa most effective chemotherapeutic agent, has been successfully used in cisplahino of a variety of solid tumors, including ovary, testis, bladder, head and neck, lung, cervix, and endometrium Baek et al.

Ten to fifteen minutes before use, CP was dissolved ciplatino saline in darkness. Thus, together with other herbal extracts, T.


A fruit of traditional Chinese medicine Sugunavarman et al. This may be related to the presence of antioxidant components acting via a multitude of nefrotoxjcidad and peripheral mechanisms. Weights of body and kidneys and apoptotic index were assessed. Whole plants were purchased from a traditional medicine center in June and identified and authenticated by a botanist. Experiments were started after one week of adaptation.


The effect of toxic dose of cisplatin 5. Cypermethrin induced reproductive toxicity in male Wistar rats: Different parts of Tribulus terrestris L have been used traditionally in treating a variety of diseases including hypertension and coronary artery diseases, diabetes and hyperlipidemia, as nefrotxicidad as fungal diseases Sharma et al.

Cellular and molecular studies on cisplatin-induced apoptotic cell death in rat kidney.


Tribulus terrestris extract protects against mercury-induced. Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-alpha.

The present study amid to investigate the Tribulus terrestris Hydroalcoholic extract effect on cisplatin-induced apoptosis in mice kidney. One of the limiting major side effects of cisplatin is nephrotoxicity.

CP nephrotoxicity pathological feature, the major adverse effect of CP in approximately one third of patients during chemotherapy in clinic, it has been the cause of renal cell damage, cell death and the loss of renal function or acute renal failure, especially in renal tubules Jiang et al.